李绍新，男，湖南临澧人，1972年7月出生，理学博士，物理学教授，硕士生导师，广东省“扬帆计划”高层次人才培养对象，现就职于广东医科大学生物医学工程学院，电子邮箱lishaox@163.com。2004毕业于华南师大激光所，获光学专业理学硕士学位，2004年至今就职于广东医科大学物理教研室，2010～2013期间在职就读华南师大光电学院，获光学专业博士学位。自2015年起，先后主持国家自然科学基金面上项目2项，省自然科学基金3项，省人才项目1项，冲补强学科建设项目2项，获授权发明专利1项，以第一作者（含共同）或通信作者（含共同）发表SCI论文20余篇。从2018年起，连续指导硕士研究生5名。
主要研究方向：
1. 生物医学光子学
生物医学光子学专注于拉曼光谱技术及其生物医学检测与诊断方法研究，如癌症的早期诊断、致病菌的快速检测等。
2. 医学人工智能
医学人工智能聚焦于病理细胞与组织的光学显微图像智能识别技术与转化研究，实现对细胞与组织病理图像的快速准确智能辅助诊断，如各类血细胞的识别，染色体畸变筛查等。
主持项目：
1. 基于代谢产物SERS光谱高灵敏测量的致病菌药敏特性快速检测方法研究，国家自然科学基金面上项目，2023
2. 医学显微图像智能识别基础与应用转化研究，广东医科大学学科建设项目， 2021
3. 深度学习联合表面增强拉曼光谱技术非标记检测尿脱落肿瘤细胞方法研究，广东省自然科学基金面上项目2021
4. 端粒酶活性的差分光学弱测量非标记检测方法研究，广东省自然科学基金面上项目2019
5. 生物医学光学成像与检测平台，广东医科大学学科建设项目，2018
6.“扬帆计划”广东省高层次人才培养对象，广东省人才项目，2017
7.循环DNA的非标记表面增强拉曼光谱定量检测方法研究，广东省自然科学基金面上项目，2017
8.循环肿瘤细胞非标记表面增强拉曼光谱鉴定方法研究，国家自然科学基金面上项目，2015
主要学术论文：
1. Wen Wang · Xin Wang · Ya Huang · Yi Zhao · Xianglin Fang · Yanguang Cong · Zhi Tang · Luzhu Chen · Jingyi Zhong · Ruoyi Li · Zhusheng Guo · Yanjiao Zhang · Shaoxin Li*. Raman spectrum combined with deep learning for precise recognition of Carbapenem-resistant Enterobacteriaceae. Anal Bioanal Chem (2024). https://doi.org/10.1007/s00216-024-05209-9
2. Xin Wang, Xingda Wu, Wen Wang, Yanguang Cong, Luzhu Chen, Jingyi Zhong, Xianglin Fang, Yongxin Tan, Yanjiao Zhang and Shaoxin Li*, Label-free rapid detection of urinary tumor cells based on surface-enhanced Raman scattering and deep learning, Laser Phys., 2023, 33(11):115601
3. Ruitong Zhao, Xin Wang, Peng Wang, Xingda Wu, Xianglin Fang, Yanjiao Zhang, Shaoxin Li*, Experimentally monitoring of the rapid biomolecular hydrolysis reaction with optical weak measurement, Laser Phys., 2022, 32(12): 125201
4. Xiaoying Zhang, Xin Wang, Mengling Ning, Peng Wang, Wen Wang, Xiaozhou Zhang, Zhiming Liu*, Yanjiao Zhang* and Shaoxin Li*,Fast Synthesis of Au Nanoparticles on Metal–Phenolic Network for Sweat SERS Analysis. Nanomaterials. 2022; 12(17):2977
5. Xiaoying Zhang, Xin Wang, Peng Wang, Qiuyue Fu, Zhaozhen Zhu, Chaocai Luo, Jieyi Chen, Yanjiao Zhang* and Shaoxin Li*. Facile synthesis of Ag-niobium ditelluride nanocomposites for the molecular fingerprint analysis of muscle tissues. Journal of Materials Chemistry, B. materials for biology and medicine, 2022(10-15).
6. Xiang-Lin Fang, Rui-Tong Zhao,Na Chen, Xin Wang, Peng Wang, Zhi-Wei He*, Shao-Xin Li*, Yang Xu, Yong-Hong He,Real-time monitoring the hydrolysis of chiral molecules by optical weak measurement, Optik，Volume 263, August 2022, 169340
7. Yang Xu, Chongqi Zhou, Dongmei Li, Cuixia Guo, Zhangyan Li, Xinhui Xing, Shaoxin Li, Tian Guan, Le Liu, Yonghong He. A stabilized weak measurement sensor for aptamer detection. Sensors and Actuators B: Chemical, 2022, 371:132509
8. Qiuyue Fu, Yanjiao Zhang, Peng Wang, Jiang Pi, Xun Qiu, Zhusheng Guo, Ya Huang, Yi Zhao, Shaoxin Li* and Junfa Xu*. Rapid identification of the resistance of urinary tract pathogenic bacteria using deep learning-based spectroscopic analysis. Analytical and Bioanalytical Chemistry. 413, 7401–7410 (2021)
9. Qiu-yue Fu, Xiang-lin Fang, Yi Zhao, Xun Qiu, Peng Wang, Shao-xin Li*. Research progress of pathogenic bacteria and their drug resistance detection based on surface enhanced Raman technology. Spectrascopy and spectra analysis. ,2022,42(5):1339-1345
10. Xianglin Fang, Shaoxin Li#, Qiuyue Fu, Peng Wang, Xingda Wu, Yanjiao Zhang,Label-free identification of lung cancer cells from blood cells based on surface-enhanced Raman scattering and support vector machine,Optik. 248,168157,2021
11. Xingda Wu, Shaoxin Li#, Qiuyan Xu, Xinliang Yan, Qiuyue Fu, Xinxin Fu, Xianglin Fang*, and Yanjiao Zhang. Rapid and accurate identification of colon cancer by Raman spectroscopy coupled with convolutional neural networks[J]. Japanese Journal of Applied Physics. 2021. 60 067001(2021)
12. XiangLin Fang, QiuYao Zeng, XinLiang Yan, Zuyi Zhao, Na Chen, QianRu Deng, MengHan Zhu, YanJiao Zhang*, and ShaoXin Li*, Fast discrimination of tumor and blood cells by label-free surface-enhanced Raman spectra and deep learning, Journal of Applied Physics，129, 123103 (2021)
13. Yanjiao Zhang, Lixuan Shi, Yang Xu, Xin Zheng, Jiawei Li, Qin Wu,Shaoxin Li*,and Yonghong He, Optic quantum weak measurement coupled with UV spectrometry for sensitively and non-separatedly detecting enantiopurity, Optics Express27(7):9330-9342 (2019)
14. Yang Xu, Lixuan Shi, Shaoxin Li*, Tian Guan, Suyi Zhong, Xuesi Zhou, Dongmei Li, Cuixia Guoa, Yuxuan Yang, Xiangnan Wang, Zhangyan Li, Yonghong He, Luyuan Xie, Zonghan Gan，Detection of Macromolecular Content in a Mixed Solution of Protein Macromolecules and Small Molecules Using a Weak Measurement Linear Differential System. Analytical Chemistry. 91(18):11576-11581 (2019)
15. Yanjiao Zhang,Qiuyao Zeng，Linfang Li，Minni Qi, Qichao Qi, Shaoxin Li*, Junfa Xu, Characterization and identification of lung cells from blood cells with lable-free surface-enhanced Raman scattering[J]. Laser Physics, 29:045602 (2019)
16. 8. Yanjiao Zhang，Qiuyao Zeng，Linfang Li，Minni Qi, Qichao Qi, Shaoxin Li*,and Junfa Xu, Label-free rapid identification of tumor cells and blood cells with silver film SERSsubstrate, Optics Express 26(25):33044-33056(2018)
17. Yanjiao Zhang, Xiaoping Lai, Qiuyao Zeng, Linfang Li, Lin Lin, Shaoxin Li*, Zhiming Liu, Chengkang Su, Minni Qi, Zhouyi Guo. Classifying low-grade and high-grade bladder cancer using label-free serum surface-enhanced Raman spectroscopy and support vector machine[J]. Laser Physics, 28:035603 (2018)
18. Yanjiao Zhang, Minni Qi, Qichao Qi, Qin Wu, Lin Lin, Shaoxin Li*, Huailing Zhang. A preliminary study of surface enhanced Raman scattering immunoassay based on graphene oxide substrate[J]. Optik, 170:146-151 (2018)
19. Shaoxin Li*, Linfang Li, Qiuyao Zeng, Yanjiao Zhang, Zhouyi Guo, Zhiming Liu, Mei Jin, Chengkang Su, Lin Lin, Junfa Xu*，and Songhao Liu, Characterization and noninvasive diagnosis of bladder cancer with serum surface enhanced Raman spectroscopy and genetic algorithms, Scientific Reports 5:9582（2015）
20. Shaoxin Li*, Yanjiao Zhang*, Junfa Xu, Linfang Li, Qiuyao Zeng, Lin Lin, Zhouyi Guo, Zhiming Liu, Honglian Xiong, and Songhao Liu, Noninvasive prostate cancer screening based on serum surface-enhanced Raman spectroscopy and support vector machine, Appl. Phys. Lett. 105: 091104 (2014)
21. Shaoxin Li*, Gong Chen, Yanjiao Zhang, Zhouyi Guo, Zhiming Liu, Junfa Xu, Xueqiang Li and Lin Lin, Identification and characterization of colorectal cancer using Raman spectroscopy and feature selection techniques. Optics Express 22(21):25895-25908(2014)
22. Shaoxin Li*, Yanjiao Zhang*, Qiuyao Zeng, Linfang Li, Zhouyi Guo, Zhiming Liu, Honglian Xiong, and Songhao Liu, Potential of cancer screening with serum surface-enhanced Raman spectroscopy and a support vector machine, Laser Phys. Lett. 11:065603 (2014)
23. Shaoxin Li*, Zhouyi Guo, Zhiming Liu, Surface-enhanced Raman spectroscopy + support vector machine: a new noninvasive method for prostate cancer screening? Expert Review of Anticancer Therapy 15(1):5-7(2015)
24. Shaoxin Li, Qiuyao Zeng, Linfang Li, Yanjiao Zhang, Mingming Wan, Zhiming Liu, Honglian Xiong, Zhouyi Guo* and Songhao Liu, Study of support vector machine and serum surface-enhanced Raman spectroscopy for noninvasive esophageal cancer detection, Journal of Biomedical Optics 18(2):027001 (2013)
25. Shaoxin Li, Qiuyan Chen, Yanjiao Zhang, Zhiming Liu, Honglian Xiong, Zhouyi Guo*, Haiqaing Mai* and Songhao Liu, Detection of nasopharyngeal cancer using confocal Raman spectroscopy and genetic algorithm technique, Journal of Biomedical Optics17(12):125003 (2012)
26. Bingling Chen, Shaoxin Li, Jianghua Li*, Zhouyi Guo, Qiuyan Chen and Haiqiang Mai*, Optimal multivariate method for Raman spectroscopy based diagnosis of nasopharyngeal carcinoma, Journal of Applied Physics, 114(24): 244702-6, 2013 (共同第一作者)
27. Jiao Gao, Yongjun Hu*, Shaoxin Li*, Yanjiao Zhang and Xue Chen, Tautomeric equilibrium of creatinine and creatininium cation in aqueous solutions explored by Raman spectroscopy and density functional theory calculations, Chemical Physics 410:81-89(2013)(共同通信)
28. Jiao Gao, Yongjun Hu*, Shaoxin Li*, Yanjiao Zhang and Xue Chen, Adsorption of benzoic acid, phthalic acid on gold substrates studied by surface-enhanced Raman scattering spectroscopy and density functional theory calculations, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 104C:41-47 (2012)(共同通信)
29. Zhiming Liu, Shaoxin Li, Chaofan Hu, Wen. Zhang, Huiqing Zhong and Zhouyi Guo*, pH-dependent surface-enhanced Raman scattering of aromatic molecules on graphene oxide, Journal of Raman Spectroscopy 44(1):75-80 (2013)
30. Zhiming Liu, Chao Hu, Shaoxin Li, Wen Zhang and Zhouyi Guo*, Rapid intracellular growth of gold nanostructures assisted by functionalized graphene oxide and its application for surface-enhanced Raman spectroscopy, Analytical Chemistry 84(23):10338-10344 (2012)
31. Ning Li, Shaoxin Li, Zhouyi Guo, Zhengfei Zhuang*, Rui Li, K Xiong, SＪChen and SＨLiu, Micro-Raman spectroscopy study of the effect of Mid-Ultraviolet radiation on erythrocyte membrane, Journal of Photochemistry and Photobiology. B, Biology 112:37-42 (2012)
32. Mingming Wan, Zhiming Liu, Shaoxin Li, Biwen. Yang, Wen. Zhang, Xiaochu. Qin and Zhouyi. Guo*, Silver nanoaggregates on chitosan functionalized graphene oxide for high-performance surface-enhanced Raman scattering, Appl Spectrosc67(7), 761-766 (2013)
33. Xu Chen,Yongjun Hu*, Jiao Gao, Yanjiao Zhang, Shaoxin Li. Interaction of melamine molecules with silver nanoparticles explored by surface-enhanced Raman scattering and density functional theory calculations. Appl Spectrosc. 67(5):491-7 (2013)
授权发明专利：
1. 李绍新,张延娇,郑鑫,李佳蔚. 一种手性分子纯度弱测量检测方法及其装置, 2019100811019.授权日期2021.08,24
