曾娟简历

曾娟，女，1985年生，党员，理学博士，副教授，硕士生导师。2014年毕业于华东师范大学原子与分子物理专业。2014-2016年于北京大学深圳研究生院从事博士后研究，2016-2018年于德国于利希研究生中心（Forschungszentrum Jülich）从事博士后研究。2019年至今于广东医科大学物理教研室工作。主要从事生物大分子的动力学模拟、计算机辅助药物设计等相关方面的研究。以第一作者或通讯作者发表SCI论文9篇；主持国家基金一项、广东省基金一项；获中德国际交流项目一项。

承担《医用物理学》、《医用电子学》等本科生教学工作。

联系邮箱：azengjuan@hotmail.com

科研项目：

1. 中国国家自然科学基金青年项目，磷酸化修饰调控4E-BP2折叠机理和作用机制的研究（21603006），2017.01-2019.12，20万元，主持。

2. 广东省自然科学基金面上项目，4E-BPs家族与eIF4E结合模式和作用机制的研究（2019A1515011079），2019.10-2022.09，10万元，主持。

代表性SCI论文：

1. Juan Zeng, Jian Chen, Fei Xia*, Qiang Cui, Xianming Deng* and Xin Xu*. Identification of functional substates of KRas during GTP hydrolysis with enhanced sampling simulations. Phys. Chem. Chem. Phys., 2022, 24, 7653.

2. Juan Zeng, Jingwei Weng, Yuwei Zhang, Fei Xia*, Qiang Cui, and Xin Xu*. Conformational Features of Ras during GTP Hydrolysis: Key Hydrogen Bond Interaction with Gln61 in Intermediate State. J. Phys. Chem. B, 2021, 125, 31, 8805–8813.

3. Juan Zeng,* and Zunnan Huang.* From Levinthal’s Paradox to the Effects of Cell Environmental Perturbation on Protein Folding. Curr. Med. Chem. 2019, 26, 7537-7554.

4. Juan Zeng, Riccardo Guareschi, Mangesh Damre, et al. Structural Prediction of the Dimeric Form of the Mammalian Translocator Membrane Protein TSPO: A Key Target for Brain Diagnostics. Int. J. Mol. Sci. 2018, 19, 2588.

5. Juan Zeng, Fan Jiang, and Yun-Dong Wu. Unravelling the folding mechanism of 4E-PB2 depended on its specific phosphorylation regulation. J. Chem. Theory Comput. 2017, 13, 320-328.

6. Juan Zeng*, Yongxiu Li, John Z. H. Zhang, and Ye Mei. Examination of the quality of various force fields and solvation models for the simulations of GA88 and GB88. J. Mol. Model. 2016, 22(8), 177.

7. Juan Zeng, Fan Jiang, and Yun-Dong Wu. Folding of a de Novo Designed -Helical Hairpin Motif using Replica-Exchange Molecular Dynamics. J. Phys. Chem. B 2016, 120, 33-41.

8. Juan Zeng, LiLi Duan, John Z.H. Zhang, and Ye Mei. A numerically stable restrained electrostatic potential charge fitting method. J. Comput. Chem. 2013, 34, 847-853.

9. Juan Zeng, Xiangyu Jia, John Z. H. Zhang, Ye Mei. The F130L mutation in streptavidin reduces its binding affinity to biotin through electronic polarization effect. J. Comput. Chem. 2013, 34, 2677-2686.